Laparoscopic Antireflux Surgery vs Esomeprazole Treatment for Chronic GERD
نویسنده
چکیده
GASTROESOPHAGEAL REFLUX disease (GERD) is a highly prevalent disorder caused by the reflux of gastric contents into the esophagus. It is a chronic, relapsing disease that negatively affects patients’ health-related quality of life and reduces work productivity. Consequently, a long-term management plan is required for each individual patient. Maintenance treatment with proton pump inhibitor (PPI) therapy may be an option, offering high rates of symptom resolution and healing of esophagitis. However, some patients are reluctant to take long-term medication and may prefer to have antireflux surgery. A number of controlled studies have been undertaken comparing open antireflux surgery and laparoscopic antireflux surgery (LARS) or open antireflux surgery and pharmaceutical treatment, but few stud-
منابع مشابه
Laparoscopic antireflux surgery vs esomeprazole treatment for chronic GERD: the LOTUS randomized clinical trial.
CONTEXT Gastroesophageal reflux disease (GERD) is a chronic, relapsing disease with symptoms that have negative effects on daily life. Two treatment options are long-term medication or surgery. OBJECTIVE To evaluate optimized esomeprazole therapy vs standardized laparoscopic antireflux surgery (LARS) in patients with GERD. DESIGN, SETTING, AND PARTICIPANTS The LOTUS trial, a 5-year explorat...
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